| 英文名称 | Anti-CCR-4（C-C chemokine receptor 4） | | 中文名称 | 细胞表面趋化因子受体4抗体 | | | | | 产品类别 | 兔抗人、大、小鼠CCR4抗体 | | 产品价格 | 0.2ml/650元 | | 产品标准 | 浓缩液（1mg/1ml） 亲和纯化抗体 | | 产品应用 | WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复） | | 产品介绍 |
趋化因子是当今细胞因子研究领域的热点之一,它参与多种免疫及炎症反应,在感染、肿瘤的生长与转移、组织修复及创伤愈合等病理生理过程中发挥重要作用.
C-C型趋化因子受体4（CCR4）在Th2细胞表面有大量表达.CCR4在肿瘤的生长与转移方面起到一定的作用。
Receptors for the C - C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5 and the Duffy blood group antigen. The C - C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR4 is preferentially expressed on type 2 helper T （Th2-type） cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Also named as C C chemokine receptor type 4 ; C C CKR 4 ; CC CKR 4 ; CCR 4 ; Chemokine （CC motif） receptor 4 ; chemokine C C motif receptor 4 ; ChemR13; CKR4; CMKBR 4; CMKBR4; HGCN 14099; K5 5; MGC88293.
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